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The study showed that the administration of 10.000 ugr of hydroxocobalamin nasal drops twice weekly was associated with a significant increase in vitamin B12 serum levels over the course of 3 months, starting from a median of 328 pmol/l (range 244429) to 973 pmol/l (range 4731,476)

The most common drug related adverse events reported in adult subjects treated with 2.5-10 g hydroxocobalamin intravenously were reddening of the urine or skin, cutaneous or pustular/papular rash, and an increase in blood pressure (Fortin et al., 2006

doi: 10.2165/00003495-199957030-00007 174 LipskyBADorrMBMagnerDJTalbotGH